March 18, 2026

Episode 21: Theresa Hoffmann (Nanoplume) - Rethinking Thermal Insulation with Bio-Based Materials

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Episode summary

Theresa Hoffmann, CEO and Co-founder of Nanoplume, discusses bio-based aerogel insulation, deep tech commercialisation, and the realities of early-stage founding on Episode 21 of Scaling Green Tech, a podcast by Adopter.

Hoffmann explains how 80% of the insulation market remains dependent on petrochemical materials, despite the thermal insulation industry growing toward a $100 billion market by 2030. Nanoplume's answer is a bio-based nano-porous material that is three times as insulating, 60% lighter and thinner, and 100% biocompatible - and around 75% cheaper than silica aerogels and other super-insulating materials. Rather than targeting the built environment first, Hoffmann describes a deliberate beachhead strategy in pharmaceutical cold chain logistics, chosen for clearer economics and lower mechanical requirements, with a roadmap toward truck insulation, warehousing, and eventually buildings. The episode also covers co-founder dynamics, founder identity, and how to validate market assumptions through early customer case studies.

This episode is relevant for deep tech founders at pre-seed and seed stage, materials science entrepreneurs, cold chain and pharmaceutical logistics investors, built environment innovators, and anyone navigating co-founder relationships, accelerator programmes, or early-stage commercialisation strategy.

Guest profile

Theresa Hoffmann is the CEO and Co-founder of Nanoplume. Before founding the company, she studied materials and process engineering and conducted human-centred design research at Stanford University, working with a professor who combined mechanical engineering with social sciences. She went on to strategy consulting at BCG, then to a venture developer role at a deep tech-focused family office, where she worked operationally with drone, laser, and data technology companies to help CEOs scale.

Nanoplume is a UK-based materials science company developing a bio-based nano-porous aerogel insulation material. Its product is three times as insulating, 60% lighter, and fully biodegradable compared to conventional insulation. The company's beachhead market is pharmaceutical cold chain logistics, with a planned expansion into the built environment. Nanoplume was formed through the Carbon 13 venture builder programme in Cambridge and subsequently went through the IndieBio accelerator in New York.

Nanoplume Website

Theresa Hoffmann LinkedIn  

Key takeaways

  • Nanoplume's bio-based aerogel insulation is three times as insulating, 60% lighter and thinner, and 100% biocompatible compared to conventional insulation - and approximately 75% cheaper than other super-insulating materials in the same segment.
  • Around 80% of insulation materials on the market are still petrochemical-based, despite the global thermal insulation industry growing toward $100 billion by 2030.
  • Aerogels have existed for almost 80 years and were used by NASA to protect the Mars Rover, but high cost, brittleness, and scaling difficulties have prevented commercialisation at volume. Hoffmann argues that bio-based feedstocks resolve these barriers.
  • A current case study with a pharmaceutical logistics customer shows a net cost saving of over £200 per shipper versus polyurethane - a six-figure reduction for a fleet of 1,000 shippers.
  • Hoffmann describes insulation as "the unsexy and silent hero in the energy transition," arguing that energy efficiency - not energy generation - is the most important lever for reaching 2030 climate goals.
  • Nanoplume's manufacturing process uses only water as a solvent, fully reused in production, with renewable polysaccharide feedstock. The finished product is fully compostable, with no end-of-life disposal cost.
  • The company is at TRL 4 approaching TRL 5, targeting TRL 6 by end of 2026, with first customer pilots in pharmaceutical cold chain currently being prepared.
  • Hoffmann identifies fragmented UK policy across building codes, circularity regulation, and energy efficiency standards as a barrier to adoption for high-performance sustainable materials, compounded by the absence of mandatory embodied carbon reporting.

topics covered

  • Describing Nanoplume to a non-technical audience
  • The problem with conventional insulation - performance, weight, and petrochemical dependency
  • What aerogels are and why bio-based feedstocks change the commercialisation case
  • Competitor landscape - super insulators, bio-based materials, and conventional products
  • Beachhead market selection - pharmaceutical cold chain and the route to the built environment
  • Customer case studies and validating total cost of ownership
  • Sustainability framing - when to lead with it and when not to
  • Embodied carbon regulation and the policy gap in the UK and internationally
  • The role of insulation in the energy transition
  • Carbon 13 and IndieBio - what each provides and for which type of founder
  • Co-founder dynamics - teaming, difficult conversations, and the Positive Intelligence saboteur framework
  • Books and tools for founders - "What Got You Here Won't Get You There," "The Culture Code," Clifton StrengthsFinder
  • Nanoplume's five-year vision - local manufacturing, waste feedstocks, and modular setups

Frequently asked questions

What is Nanoplume's insulation material made from?
What is an aerogel and why hasn't it been commercialised before?
What is Nanoplume's beachhead market and why?
How does Nanoplume calculate ROI for customers?
What is the role of insulation in the energy transition?
What is the UK embodied carbon regulation gap?
What are Carbon 13 and IndieBio and how did they shape Nanoplume?

About Scaling Green-Tech

Scaling Green-Tech by Adopter is a podcast for people shaping the future of climate technology - founders, investors, and ecosystem leaders at the forefront of adaptation and resilience solutions. As part of Adopter’s mission to accelerate the adoption of high-impact climate innovation, the podcast aims to amplify real voices and practical insights that can help others navigate the startup journey. These conversations go beyond the hype to bring real, unfiltered stories - the wins, the roadblocks and everything you need to know in between.

Read the full transcript here
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