March 18, 2026

Episode 21: Theresa Hoffmann (Nanoplume) - Rethinking Thermal Insulation with Bio-Based Materials

Logo of Adopter - the marketing agency for deep tech and climate adaptation.

Theresa Hoffmann, CEO and Co-founder of Nanoplume, discusses bio-based aerogel insulation, deep tech commercialisation, and the realities of early-stage founding on Episode 21 of Scaling Green Tech, a podcast by Adopter.

Hoffmann explains how 80% of the insulation market remains dependent on petrochemical materials, despite the thermal insulation industry growing toward a $100 billion market by 2030. Nanoplume's answer is a bio-based nano-porous material that is three times as insulating, 60% lighter and thinner, and 100% biocompatible - and around 75% cheaper than silica aerogels and other super-insulating materials. Rather than targeting the built environment first, Hoffmann describes a deliberate beachhead strategy in pharmaceutical cold chain logistics, chosen for clearer economics and lower mechanical requirements, with a roadmap toward truck insulation, warehousing, and eventually buildings. The episode also covers co-founder dynamics, founder identity, and how to validate market assumptions through early customer case studies.

This episode is relevant for deep tech founders at pre-seed and seed stage, materials science entrepreneurs, cold chain and pharmaceutical logistics investors, built environment innovators, and anyone navigating co-founder relationships, accelerator programmes, or early-stage commercialisation strategy.

Guest Profile

Theresa Hoffmann is the CEO and Co-founder of Nanoplume. Before founding the company, she studied materials and process engineering and conducted human-centred design research at Stanford University, working with a professor who combined mechanical engineering with social sciences. She went on to strategy consulting at BCG, then to a venture developer role at a deep tech-focused family office, where she worked operationally with drone, laser, and data technology companies to help CEOs scale.

Nanoplume is a UK-based materials science company developing a bio-based nano-porous aerogel insulation material. Its product is three times as insulating, 60% lighter, and fully biodegradable compared to conventional insulation. The company's beachhead market is pharmaceutical cold chain logistics, with a planned expansion into the built environment. Nanoplume was formed through the Carbon 13 venture builder programme in Cambridge and subsequently went through the IndieBio accelerator in New York.

Nanoplume Website

Theresa Hoffmann LinkedIn  

Key Takeaways

  • Nanoplume's bio-based aerogel insulation is three times as insulating, 60% lighter and thinner, and 100% biocompatible compared to conventional insulation - and approximately 75% cheaper than other super-insulating materials in the same segment.
  • Around 80% of insulation materials on the market are still petrochemical-based, despite the global thermal insulation industry growing toward $100 billion by 2030.
  • Aerogels have existed for almost 80 years and were used by NASA to protect the Mars Rover, but high cost, brittleness, and scaling difficulties have prevented commercialisation at volume. Hoffmann argues that bio-based feedstocks resolve these barriers.
  • A current case study with a pharmaceutical logistics customer shows a net cost saving of over £200 per shipper versus polyurethane - a six-figure reduction for a fleet of 1,000 shippers.
  • Hoffmann describes insulation as "the unsexy and silent hero in the energy transition," arguing that energy efficiency - not energy generation - is the most important lever for reaching 2030 climate goals.
  • Nanoplume's manufacturing process uses only water as a solvent, fully reused in production, with renewable polysaccharide feedstock. The finished product is fully compostable, with no end-of-life disposal cost.
  • The company is at TRL 4 approaching TRL 5, targeting TRL 6 by end of 2026, with first customer pilots in pharmaceutical cold chain currently being prepared.
  • Hoffmann identifies fragmented UK policy across building codes, circularity regulation, and energy efficiency standards as a barrier to adoption for high-performance sustainable materials, compounded by the absence of mandatory embodied carbon reporting.

FAQs

  1. What is Nanoplume's insulation material made from? 

Nanoplume's material is a bio-based nano-porous aerogel made from polysaccharides - renewable, abundant feedstocks. The manufacturing process uses only water as a solvent, fully reused in production. The finished material is biodegradable and compostable at end of life, with no petrochemical content and no disposal cost.

  1. What is an aerogel and why hasn't it been commercialised before? 

An aerogel is an extremely porous solid - the best examples have 99.9% porosity, meaning only 0.1% solid content. Aerogels have existed for nearly 80 years and been used in applications including NASA's Mars Rover missions, but high manufacturing cost, brittleness, and difficult scaling have blocked mainstream adoption. Nanoplume uses bio-based feedstocks, which Hoffmann argues enables cheaper production at higher volumes than classical silica-based aerogels.

  1. What is Nanoplume's beachhead market and why? 

Nanoplume's beachhead market is single-use pharmaceutical cold chain logistics - smaller volume shippers for temperature-sensitive medical products. Hoffmann chose this market because it is less price-sensitive than general logistics, offers clear instant ROI from reduced volume and weight, and does not require the high mechanical strength the material will need for built environment applications. The roadmap runs from pharmaceutical shippers to pallet shippers, then truck insulation, then warehouse insulation, and eventually buildings.

  1. How does Nanoplume calculate ROI for customers? 

Nanoplume builds case studies that model total cost of ownership rather than upfront material cost alone. For a pharmaceutical pallet shipper currently using polyurethane, the calculation covers material volume, shipping weight, and end-of-life disposal. Because Nanoplume's material is higher-performing, less is needed; because it is lighter, shipping costs fall; because it is compostable, disposal costs are eliminated. The net saving in one active case study is over £200 per shipper.

  1. What is the role of insulation in the energy transition? 

Hoffmann argues that insulation is underweighted in energy transition conversations, which tend to focus on generation technologies like wind, solar, and hydrogen. Her position is that avoiding energy production in the first place is the most carbon-efficient approach - and insulation is a primary mechanism for doing that. In buildings, it determines energy consumption and grid demand. In cold chain, it determines fuel use. Nanoplume describes energy efficiency, not energy generation, as the key to reaching 2030 climate targets.

  1. What is the UK embodied carbon regulation gap? 

Embodied carbon is the carbon emitted in the manufacture, transport, and installation of building materials, distinct from operational carbon from energy use. As of early 2026, the UK has not introduced mandatory embodied carbon reporting for new builds. Hoffmann says this slows adoption of high-performance sustainable materials because buyers default to upfront cost comparisons rather than whole-lifecycle value. Nanoplume has embodied carbon data prepared and performs competitively against conventional materials on this measure.

  1. What are Carbon 13 and IndieBio and how did they shape Nanoplume? 

Carbon 13 is a Cambridge-based venture builder programme focused on climate-relevant deep tech. It dedicates 10 weeks to co-founder teaming before moving to company formation - Nanoplume's founding team met through this process. IndieBio is a New York-based accelerator investing in life science and deep tech companies at early stage. After Carbon 13, Nanoplume received IndieBio investment and completed a three-to-four month programme in New York, gaining laboratory access, pitch coaching, product video support, and investor network. Hoffmann credits Carbon 13 for the co-founder relationship and IndieBio for speed, storytelling, and network.

Topics Covered

  • Describing Nanoplume to a non-technical audience
  • The problem with conventional insulation - performance, weight, and petrochemical dependency
  • What aerogels are and why bio-based feedstocks change the commercialisation case
  • Competitor landscape - super insulators, bio-based materials, and conventional products
  • Beachhead market selection - pharmaceutical cold chain and the route to the built environment
  • Customer case studies and validating total cost of ownership
  • Sustainability framing - when to lead with it and when not to
  • Embodied carbon regulation and the policy gap in the UK and internationally
  • The role of insulation in the energy transition
  • Carbon 13 and IndieBio - what each provides and for which type of founder
  • Co-founder dynamics - teaming, difficult conversations, and the Positive Intelligence saboteur framework
  • Books and tools for founders - "What Got You Here Won't Get You There," "The Culture Code," Clifton StrengthsFinder
  • Nanoplume's five-year vision - local manufacturing, waste feedstocks, and modular setups

Related Content

Episode 17: Amandeep Kalra (GreenFlip) - Unlocking the ROI in Decarbonising Homes 

Episode 11: Anne Snelson and Becky Lane (Furbnow) - Accelerating the Home Energy Transition

Episode 7: Dr Aled Roberts (Dekiln) - Creating the World’s Most Sustainable Tiles 

Strategy & messaging for deep tech and climate adaptation companies

About Scaling Green-Tech

Scaling Green-Tech by Adopter is a podcast for people shaping the future of climate technology - founders, investors, and ecosystem leaders at the forefront of adaptation and resilience solutions. As part of Adopter’s mission to accelerate the adoption of high-impact climate innovation, the podcast aims to amplify real voices and practical insights that can help others navigate the startup journey. These conversations go beyond the hype to bring real, unfiltered stories - the wins, the roadblocks and everything you need to know in between.

Read the full transcript here
illustration of Earth